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There are 16 clues with the answer 'GREATPLAINS'
# CLUE
1.
It's known as "the Prairies" in Canada
2.
Vast expanse from Canada to Texas
3.
Buffalo roaming ground
4.
A vast region of North America east of the Rocky Mountains (5,6)
5.
Simple to enter university course in parts of America
6.
Large area of central US
7.
Grassland area E of Rockies
8.
American grassland
9.
Nebraska's region
10.
Vast Canada-to-Mexico ranching expanse
11.
Region that includes parts of 10 U.S. states
12.
North American expanse once home to over 30 Native tribes
13.
Vast flat region of North America east of the Rocky Mountains, used extensively for cattle farming (5,6)
14.
Vast area east of the Rocky Mountains (5,6)
15.
Expanse of land stretching from Texas to Canada
16.
A vast region of North America, east of the Rocky Mountains (5,6)