Across and Down

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There are 11 clues with the answer 'INEFFICACY'
# CLUE
1.
Caffeine reduced in treatment during cold - lack of capacity to work (10)
2.
Without skill
3.
Shortage
4.
Not efficacy
5.
Not capability
6.
Letdown
7.
Inadequacy
8.
Inability
9.
Futility
10.
Disappointment
11.
Smearing Fife, a cynic not working