Across and Down

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There are 72 clues with the answer 'REINA'
# CLUE
1.
Sophia or Isabel
2.
Aptly, she reigns in Spain
3.
Royal of 27-Across
4.
Mother of a prA-ncipe
5.
Madrid's ___ SofA-a Art Center
6.
Isabel, por ejemplo
7.
Sofia, por ejemplo
8.
Spain's Isabel I, e.g.
9.
MarA-a Luisa, for one
10.
MarA-a Cristina, for one
11.
Queen Letizia, por ejemplo
12.
Queen, en Espanol
13.
Isabel II, for one
14.
Alfonso's "queen"
15.
Queen, in Juarez
16.
Queen, in Spanish
17.
Felipe VI's wife Letizia of Espana, e.g.
18.
Goalkeeper Pepe
19.
Isabella I, por ejemplo
20.
Isabella II, por ejemplo
21.
Pepe ....., Barcelona, Villarreal, Liverpool and Spain goalkeeper (5)
22.
Queen in un palacio
23.
Claudio ..... , former US captain at Manchester City from 2003-07 (5)
24.
"Palacio" leader
25.
Isabel I, por ejemplo
26.
Royal in un palacio
27.
___ in; brings under control
28.
Juana, for one
29.
Queen, in Spain
30.
Castile's "Juana la Loca," for one