| EVILTWIN | "The Dark Mirror" antagonist, e.g. |
| LOYALIST | American Revolution antagonist, e.g. |
| MADDOG | Nickname of Buford Tannen, the main antagonist of the film Back to the Future Part III (3,3) |
| VOLDEMORT | Main antagonist of the Harry Potter series who is also known as The Dark Lord |
| LER | The Once-___ (antagonist in "The Lorax") |
| SITH | The main antagonist group in the Star Wars franchise |
| KARATEKID | 1984 movie with the main antagonist Sensei John Kreese, with "The" |
| BOWSER | The main antagonist in the Super Mario video games (6) |
| SCORCH | In the DC Comics series, the alter ego of Aubrey Sparks and an antagonist of Superman |
| VILLAIN | The main evil character and antagonist to the hero in a novel, play, film, etc (7) |
| SNOW | Coriolanus ___, ruler of Panem and the main antagonist in The Hunger Games series of novels |
| BIFF | First name of George McFly's antagonist in the Back to the Future film series |
| COYOTE | Wile E. _ _ _ _ _ _, antagonist of the Road Runner in the Looney Tunes cartoon (6) |
| GASTON | Antagonist in Disney's "Beauty and the Beast" |
| MOTOR | Final antagonist in Othello is the driving force (5) |
| SCAR | Antagonist for Simba and Mufasa in "The Lion King" |
| ROTH | Hyman ___, main antagonist in "The Godfather Part II" |
| HOGG | 'The Dukes of Hazzard' antagonist Boss ___ |
| CALIBAN | Antagonist from The Tempest (7) |
| JUNO | Antagonist in the "Aeneid" |
