| LUBBOCK | A city in North West Texas, centre of a cotton-growing region (7) |
| CHOCTAW | In 1820, which Native American tribe ceded five million acres in Mississippi for cotton growing? (7) |
| SEATTLE | Land ringing a city in north-west America |
| PRESTON | City in north-west England (pop 114,000). It obtained city status in 2002. (7) |
| GENOESE | Citizen of a seaport city in north-west Italy (7) |
| AMARILLO | An industrial city in North West Texas, the largest in the Texas Panhandle (8) |
| LEONESE | Relating to a city in north-east Spain (pop about 125,000) (7) |
| WHITNEY | Eli, US inventor of a cotton gin (7) |
| ALGIERS | City in north-west Africa and ancient Mediterranean port (7) |
| CHESTER | City in north-west England on the River Dee (7) |
| ABILENE | West Texas Rodeo town |
| SANPEDROSULA | A city in north-west Honduras; its chief industrial centre (3,5,4) |
| ROUEN | A city in North France, on the River Seine, the scene of the burning of Joan of Arc in 1431 (5) |
| FORTWORTH | A city in north Texas, at the junction of the Clear and West forks of the Trinity River (4,5) |
| ASTI | A city in North West Italy famous for its sparkling wine (4) |
| OLDENBURG | A city in north-west Germany on the Rivers Hunte and Haaren (9) |
| LIVERPOOL | A city in North West England, on the Mersey estuary (9) |
| BOLL | Word for a bubble originally, now a rounded seed-capsule of a cotton or flax plant; or, a poppy-head (4) |
| NAZARETH | A city in North Israel, the home of Jesus in his youth (8) |
| BILBAO | A city in North Spain, the largest city in the Basque Country (6) |
