| CATTALO | A cross between the American buffalo and the domestic cow (7) |
| SHIHTZU | Dog, a cross between the Pekingese and the Tibetan Apso (4,3) |
| SAVANNAH | New hybrid feline breed which blends the characteristics of the serval and the domestic cat |
| CHANNEL | The sound that will make you cross between the French and the English (7) |
| KATEBOSWORTH | Actress of the horror films Before I Wake and The Domestics (4,8) |
| BEEFALO | In the United States, a hybrid animal that is three-eighths bison and five-eighths domestic cow, bred for food (7) |
| BIGFIVE | The lion, elephant, rhino, buffalo and leopard (3,4) |
| DAVIDMAMET | Author of the stage plays American Buffalo and Speed-the-Plow (5,5) |
| WILDCAT | Creature, Felis silvestris, that is regarded as the ancestor of the domestic cat (7) |
| BEDROOM | In The -, domestic drama for Tom Wilkinson and Sissy Spacek (7) |
| CHICKEN | Name the young of the domestic fowl (7) |
| ROOSTER | What is the male of the domestic fowl (7) |
| NIGELLA | ____ Bites, 2001 cookbook by the food writer dubbed the Domestic Goddess (7) |
| MAMET | David ___, author of stage plays American Buffalo and Speed-the-Plow (5) |
| DAVID | Author of stage plays American Buffalo and Speed-the-Plow (5,5) |
| SERVANT | Civil he may be, the domestic! (7) |
| NEWDEAL | The domestic policies of Franklin D. Roosevelt for economic and social reform (3,4) |
| COXCOMB | Red crest on the head of the domestic fowl |
| GREYLAG | Ancestor of the domestic goose (7) |
| PLUMBER | Person who repairs the domestic apparatus of water supply systems |
