| STRADIVARIUS | A stringed instrument made by an Italian luthier born in 1644 (12) |
| STRADIVARI | Italian luthier born in Cremona and estimated to have made over 1000 instruments (10) |
| PENN | William, English religious thinker and influential Quaker born in 1644 (4) |
| AVOGADROSLAW | Principle concerning the number of molecules in gases, formulated by an Italian physicist |
| PENNYWHISTLE | Instrument made by girl while crossing street (5,7) |
| STRAD | Short word for a violin or other instrument made by luthier "Antonio", such as the Lady Blunt or one owned by Sherlock Holmes (5) |
| GLOBEATRE | London landmark destroyed by the Puritans in 1644 |
| DELGESU | Nickname of the Italian luthier from Cremona, Giuseppe Guarneri (3,4) |
| URBAN | Name of eight popes, the last one dying in 1644 (5) |
| ZITHER | Stringed instrument made famous by soundtrack to The Third Man (1949) (6) |
| LYRE | Ancient stringed instrument made out of a tortoiseshell |
| ALTHORN | Instrument made by singer with husband in navy |
| AMATI | To begin with, a masterful artist tries instrument made by renowned violin-making family |
| MING | Chinese dynasty that ended in 1644 |
| POMADE | Manufactured by an Italian river, you put it in your hair (6) |
| AIDA | Opera set in Egypt and written by an Italian |
| ATCO | In the UK (formerly the Atlas Chain Company, and now owned by an Italian conglomerate) (4) |
| GALILEAN | ____ moons, largest four of Jupiter first seen by an Italian astronomer in 1609-10 (8) |
| CARBURETTOR | Air and fuel are mixed in this vehicle by an Italian pistol maker, reportedly (11) |
| VIOLA | One of the stringed musical instruments made by Andrea Amati or Gasparo da Sale); or, a flower related to the pansy (5) |
