| LEM | Abbreviated name of Apollo 11's moon lander (3) |
| SEA | Area on the moon that was the landing site of Apollo 11's lunar module, the ... of Tranquility |
| ORION | Name of Apollo 16's lunar lander |
| PHOEBUS | Name of Apollo as the sun god in Greek mythology (7) |
| ISA | Abbreviated name of a type of tax-free savings account (3) |
| DNA | Abbreviated name of a double helix-shaped molecule carrying an organism's genetic code/material (3) |
| ACE | Abbreviated name of a former SR West Country express (1,1,1) |
| RAS | Abbreviated name of the UK's learned society dedicated to solar-system science, conceived over dinner by Charles Babbage, Sir John Herschel and others in 1820 (1,1,1) |
| RHS | The abbreviated name of a botanical society co-founded by Josiah Wedgwood's son, John (1,1,1) |
| HAY | Alfalfa, clover, ryegrass, timothy etc cut and dried as fodder; a country dance; or, the abbreviated name for the "town of books" that hosts an annual literary festival (3) |
| LIL | Abbreviated name for 39A's granddaughter Lily in Walford (3) |
| SAL | Tim Metcalfe's abbreviated name for his wife in Corrie (3) |
| PEMBO | Abbreviated name of a county that gave its name to a breed of Corgi, where Tenby and Marloes form part of one of the three Welsh national parks (5) |
| IPA | Abbreviated name for a hoppy style of beer, made in Britain since about 1835 |
| STBARTS | Abbreviated name of an overseas collectivity of France forming part of the Leeward Islands archipela |
| NOTTS | Abbreviated name of the county famous for the legends of Robin Hood and as the site of Sherwood Fore |
| MTOSSA | Abbreviated name of a mountain south of Olympus in Thessaly associated with the myth of the Aloadae giants; or, the highest peak in Tasmania (2,4) |
| NASA | Abbreviated name of the agency that implemented the Apollo missions that landed men on the Moon (1,1,1,1) |
| STTROPEZ | Abbreviated name of a town on the French Riviera south-west of Nice and Cannes, site of the old fishing district La Ponche (2-6) |
| LNER | Abbreviated name of the second largest of the 'Big Four' railway companies created by the Railways Act of 1921 in Britain |
