| IVORY | After four, Roy circulated banned substance (5) |
| JESUS | Spanish footballer who returned to Sevilla in 2017 after four years at Manchester City (5,5) |
| NAVAS | Spanish footballer who returned to Sevilla in 2017 after four years at Manchester City (5,5) |
| IVANA | An ace after four trump (5) |
| PATSY | _ Palmer, has reprised her role as Bianca Jackson in EastEnders after four years (5) |
| BALLS | Take a walk after four of these |
| PLANE | After four failed schemes, devise this carpentry tool? |
| DDT | Wrestling move named after a banned substance |
| PED | Banned substance in pro sports, for short |
| STEROID | Heavenly body without a banned substance (7) |
| ASBESTOS | Beasts so affected by banned substance (8) |
| NARCOTIC | Banned substance on Arctic Monkeys? (8) |
| CHEETAH | Fast runner, one taking banned substance reportedly? (7) |
| ROID | Banned substance, shortly |
| DRUG | Banned substance ultimately recommended to runner (4) |
| AGENTORANGE | A banned substance coating man and ape, this defoliant |
| LSD | Banned substance |
| ROBIN | With 35-Across: creator and star of 12-Across, who said goodbye to her show at the Emmys on Monday after four seasons; it had been nominated for four Emmys along the way |
| TEENAGEMUTANTNINJATURTLES | Comic book characters named after four Renaissance Italian artists (7,6,5,7) |
| STEROIDS | Banned substances used by athletes to enhance performance |
