| ASUNCION | Capital city and chief port of Paraguay, founded by Spanish settlers in 1537 (8) |
| MARACAIBO | Second-largest city of Venezuela, founded as Nueva Zamora by Spanish settlers in 1574 (9) |
| SANTIAGO | Capital of Chile, founded by Spanish conquistador Pedro de Valdivia in 1541 (8) |
| CHIHUAHUA | Breed of small toy dog introduced into Mexico by Spanish settlers (9) |
| CREOLE | In Louisiana, a French-speaking descendant of early French or Spanish settlers (6) |
| OPUSDEI | Strict Roman Catholic organisation founded by Spanish priest Josemaria Escri in 1928 (4,3) |
| TERESINA | Capital city and chief port of the state of Piaui in NE Brazil, on the Parnaiba River (8) |
| LIMASSOL | Second-largest city and chief port of Cyprus, in the south on Akrotiri Bay (8) |
| FREETOWN | Capital city and seaport in west Africa (pop about 1 million), founded in the late 18th century (8) |
| HELSINKI | Capital city and port on the Gulf of Finland (8) |
| LILONGWE | The capital city and largest city of Malawi (8) |
| HONOLULU | Capital city and port of Hawaii (8) |
| LOME | Capital city and chief port of Togo, in the south-west on the Gulf of Guinea (4) |
| SUVA | Capital city and chief port of Fiji, on the SE coast of the island of Viti Levu (4) |
| SANJUAN | Capital city and chief port of Puerto Rico, founded as Ciudad de Puerto Rico in 1521 (3,4) |
| ISTANBUL | City and chief seaport of Turkey (8) |
| NASSAU | Capital city and chief port of the Bahamas, on the NE coast of New Providence Island (6) |
| GEORGETOWN | Capital city and chief port of Guyana, on the Atlantic Ocean at the mouth of the Demerara River (10) |
| MALABO | Capital city and chief port of Equatorial Guinea, formerly (until 1973) called Santa Isabel (6) |
| TRIPOLI | Capital city and chief port of Libya on the Mediterranean (7) |
