| AMARILLO | City in northwest Texas, US, formerly associated with the helium industry |
| COMANCHE | Northwest Texas native |
| LUBBOCK | City in NW Texas devastated by a tornado in 1970 (7) |
| OKLAHOMA | Neighbour of Texas, USA |
| ABILENE | University town in central Texas, US associated with the oil refining industry (7) |
| NOBLE | Any of the inert gaseous elements of the helium group in the periodic table (5) |
| WACO | City in east-central Texas, US, on the Brazos River |
| ELPASO | City in Texas, US, on the Rio Grande opposite Ciudad Juarez, Mexico (2,4) |
| GALVESTON | Coastal city in SE Texas, US famously struck by a hurricane in 1900 (9) |
| YOUNGSTOWN | City in Ohio, US formerly known as a centre of steel production (10) |
| WICHITA | City in N Texas, US, south of Sheppard Air Force Base (7,5) |
| BROWNSVILLE | Port on the Rio Grande, Texas, US, across the border from Matamoros, Mexico (11) |
| HOUSTON | Inland port in SE Texas, US; site of the Lyndon B Johnson Space Center (7) |
| FALLS | City in N Texas, US, south of Sheppard Air Force Base (7,5) |
| OHARE | International airport in Chicago, US formerly called Orchard Field (5) |
| GASMEN | They make you laugh, as they're supposed to check the helium in the air presumably (6) |
| INERTGASES | One of the terms for the monatomic "noble" elements or argonons of the helium group (5,5) |
| ARGONON | Any of the inert gaseous elements of the Helium group (7) |
| DOUBLEHELIX | Twice the helium and lithium unknown in molecule |
| SWEETW | Northwest Texas city |
