| CENTAURUS | Constellation symbolised by a half human, half horse creature (9) |
| CENTAUR | Mythological Greek half human, half horse creature such as Chiron (7) |
| LAMB | 2021 folk horror film featuring a half-human, half-sheep hybrid |
| CRUX | A cross; a southern constellation symbolised by said figure; a vital point or stage; a baffling problem or puzzle; or, the hardest point of a climb (4) |
| FAUN | A half-human and half-goat creature in Greek and Roman mythology (4) |
| YORKSHIRE | Divided into three ridings, a county symbolised by a white rose where an annual UCI road cycling race is hosted (9) |
| CAPRICORN | Zodiacal sign symbolised by a goat (9) |
| SATYR | Half human, half horse, deity |
| CENTAURS | Half man/half horse creatures of ancient mythology |
| NAGA | A divine half-human, half-cobra being in Hinduism, said to reside in a resplendent jewelled palace (4) |
| STEVENUNIVERSE | Half-human half-alien title character in a current Cartoon Network series: 2 wds. |
| HARPY | Half-human, half-bird creature, in myth |
| SPOCK | Who is half-human, half-vulcan? (5) |
| TROI | Half-human, half-Betazoid character in Star Trek: The Next Generation, Deanna ... (4) |
| CYBORG | Sci-fi character that's half-human half-machine |
| ERMA | Half-human/half-ghost Williams of web comics |
| HARPIES | Half-human, half-bird mythological figures (7) |
| MERC | A short or informal name of a car symbolised by a three-pointed star; or, a soldier of fortune (4) |
| DOT | In music, the symbol placed after a note to increase its time value by a half |
| ARCLIGHT | Illumination provided by a half-moon? (3-5) |
