| BISMUTH | Element with a unique last letter |
| COBALT | One of only four elements with a unique last letter |
| PLATES | "I cannot do another dinner at a restaurant that does small ___ with a unique flare!" (Gregory's reason for breaking up with Taylor in "Abbott Elementary") |
| OYSTER | From "bone, shell, tile", a "huitre" with a unique "merroir" and valves sometimes encasing a gem symbolic of endless possibilities; or, the greyish-pinkish beige colour of said shucks (6) |
| OPALINE | Milk glass; or, pertaining to a gem with a unique play of rainbow colours, a word for nacreous, iridescent, pearly, polychromatic or prismatic (7) |
| ONEHORSETOWN | Place with a unique mode of transport (3-5,4) |
| HORSE | Tennessee Walking __ (equine with a unique gait) |
| PEAR | Fruit with a unique shape |
| DORITOSLOCOS | Taco Bell taco variety with a unique shell |
| MALLSANTA | Seasonal worker with a unique dress code |
| AUTEUR | Director with a unique style |
| BOTTLENOSE | Dolphin with a unique beak |
| NOSE | Cat part with a unique print |
| INVENT | Surprise the world with a unique creation, as Edison did |
| NARWHAL | Large marine mammal with a unique spiral tusk |
| NORTHAM | Small north Devon town with a unique pebble ridge (7) |
| ETON | School in Berkshire with a unique system of house and sporting colours (4) |
| EQUINEINFLUENZA | Horse's condition variable housed in converted inn with a unique feel (6,9) |
| ISOTOPE | A variety of a chemical element with a different mass number to the others (7) |
| TIN | Only chemical element with a three-letter name |
