| LONELINESS | Feeling of isolation |
| LONESOMELY | With a feeling of isolation |
| QUARANTINE | A period of isolation or detention, especially of persons or animals arriving from abroad, to prevent the spread of disease |
| THESTICKS | Seconds after ending of contract, he's in a place of isolation |
| SIEGES | Military actions of isolation and attack (6) |
| EXILE | Place of isolation |
| STERILE | Unproductive state of isolation ward? (7) |
| CABINFEVER | *Symptom of isolation, perhaps |
| ALIENATION | The greatest emerging leader from China in a state of isolation (10) |
| COMEINFROMTHECOLD | Enter house in winter and gain acceptance after period of isolation (4,2,4,3,4) |
| THECOLD | Enter house in winter and gain acceptance after period of isolation (4,2,4,3,4) |
| COMEINFROM | Enter house in winter and gain acceptance after period of isolation (4,2,4,3,4) |
| OBRIEN | Edna ___, author of The Country Girls (1962) and House of Splendid Isolation (1994) (6) |
| BLOCKADE | Isolation of place by sea (8) |
| RADIUM | Subject of Marie Curie's isolation |
| SOLITUDE | Isolation of repositioned outside left included (8) |
| SOLITARINESS | Isolation (of a hermit?) (12) |
| PURDAH | Enforced isolation of women (6) |
| SEGA | Publisher of the video game Alien: Isolation |
| SOLICITUDE | Concern of one caught in isolation (10) |
