| STLEO | Fifth-century pope, the first to receive the title "the Great" |
| PETER | Pope the first |
| LEOI | First pope with the title "the Great" |
| CYRUS | Ruler of Persia, 559-530 BCE, who was given the title 'the great' (5) |
| OPENER | Old writer the Queen is the first to receive? |
| SAINTLEO | Fifth-century pope who was the first to be called "the Great" |
| LICENSEDTOKILL | 1965 film starring Tom Adams as secret agent Charles Vine, released in the US under the title The Second Best Secret Agent in the Whole Wide World |
| DOORMAN | He's the first to receive callers (7) |
| LORENZO | Italian statesman and patron of the Renaissance who was given the title 'the Magnificent (7) |
| JAMESDEAN | Rebel Without A Cause actor who became the first to receive a posthumous nomination for an Oscar (5, |
| DEAN | Actor known for his work in Rebel Without a Cause (1955), and the first to receive a posthumous Best Actor Oscar nomination (last name only) (4) |
| ISABELLA | Spanish queen who was given the title "the Catholic" |
| STLEOI | Canonized fifth-century pope called "the Great" |
| ELBE | Royal treatment: Mr. Elba, dashing actor who in 2016 chose his mum to escort him to Buckingham Palace to receive the honor of membership in the Order of the British Empire |
| SINCLAIR | The first author from the USA to receive the Nobel Prize in Literature, _ Lewis (8) |
| RUFF | A reeve's male counterpart, named for its distinguishing frill or collar of ornamental neck feathers in the breeding season; the perch-like pope; the old card game "trump"; or, a low vibrating beat of |
| PEOPLE | Folk who upset the Pope, the French (6) |
| LOUISWASHKANSKY | Patient who was the world's first to receive a heart transplant in 1967 (5,10) |
| GRAMMY | Injured nurses first to receive award (6) |
| CAKED | Church dignitary's first to receive honours, laid on thick |
