| TRANSVAAL | Former South African province founded in 1852 (9) |
| POSTNATAL | Following birth former South African province gets behind with mail (9) |
| ORMOND | Great ___ Street, children's hospital in London founded in 1852 (6) |
| TUFTS | Private research university in Massachusetts founded in 1852 (5) |
| NATURAL | Unpretentious old city in former South African province (7) |
| NATAL | Having to do with birth in former South African province |
| APARTHEID | Former South African system of segregation |
| VICTORIAANDALBERT | London museum founded in 1852 |
| ORANGEFREESTATE | Former South African province |
| NATALIE | Wood from former South African province, that is (7) |
| FARGO | Company founded in 1852 to provide express and banking services to California (5,5) |
| WELLS | Company founded in 1852 to provide express and banking services to California (5,5) |
| GERARD | Etienne Maurice ?, prime minister of France in 1834 who died in 1852 |
| SANBERNARDINO | Californian city founded by Mormons in 1852 (3,10) |
| ROGETSTHESAURUS | Reference work with synonyms and antonyms first published in 1852 (6,9) |
| ROGET | Whose thesaurus, published in 1852, is still in use today? (5) |
| BALMORAL | Royal residence in Scotland that was purchased by Prince Albert in 1852 (8) |
| DEEPSEACABLE | In 1852, British engineer Frederic Newton Gisborne's contribution to submarine telegraphy was the laying of a ___-___ ___ (the first one in North America) connecting New Brunswick and Prince Edward Is |
| COMPROMISER | "The Great ___" (nickname of Henry Clay owing to his prowess in appeasing slaveholding states; he died in 1852 during his fourth stint as a U.S. senator for Kentucky) |
| FOUCAULT | French physicist who named and improved the gyroscope in 1852 (8) |
