| FRAISE | French word for a strawberry that is also eau-de-vie distilled from such; a 16th-century neck ruff; a horizontal palisade; or, a horological tool (6) |
| FRAMBOISE | From "ambrosial strawberry, blackberry, bramble", French word for a raspberry; its colour; or, eau de vie or other liquor distilled from its juice (9) |
| MALL | This word originated from a 16th-century Italian game called pallamaglio and referred to the alley where the game was played. Now, it means a large shopping area. |
| BUSSYDAMBOIS | Jacobean stage play by George Chapman whose title character is based on a 16th-century French noblem |
| MANOR | Occupying a 16th-century building two miles from Upholland rail station, Lancashire ___ Hotel, is found at East Pimbo, Skelmersdale (5) |
| PALLADIAN | A European style of architecture inspired by the designs of a 16th Century Venetian architect (9) |
| CAMINO | "Any important highway," in Spain; a 16th-century highway that connected the cities of Gijon, Leon, and Madrid (6) |
| FUCHSIA | Genus of shrubs cultivated for their showy drooping flowers named after a 16th-century German botanist (7) |
| TITIAN | Allegedly living until he was 103, a 16th-century painter synonymous with a shade of striking red (6) |
| ERASTIANISM | Doctrine that the state should supersede the Church in ecclesiastical matters, named (erroneously) after a 16th-century Swiss theologian (11) |
| ANABAPTISTS | Members of a 16th-century Protestant movement that believed in complete separation of church and state (11) |
| KIRSCH | Meaning "cherry", a type of morello eau de vie, enjoyed as an aperitif, as a flavouring in Black Forest gateau or in the centres of chocolate liqueurs (6) |
| LUTHERAN | A Protestant following the teachings of a 16th-century German monk (8) |
| CALVADOS | French cider brandy (eau-de-vie) produced in an eponymous region of Normandy since 1553 (8) |
| SIDNEY | And 23 College of the University of Cambridge named after a 16th Century countess (6,6) |
| CODPIECE | What do you call the 'Cup' worn over a 16th-century man's breeches? (8) |
| ADIEU | Eve leaves eau de vie with a goodbye (5) |
| LUMPBRANDY | Eau de vie applied to a head injury to reduce swelling? |
| ARMAGNAC | Eau de vie from Gascony |
| COGNAC | French variety of eau de vie (6) |
