| RAFT | Huckleberry Finn took one down the Mississippi River |
| LASALLE | The Chickasaw were waiting for this French explorer when he made his way down the Mississippi in 1682 (2,5) |
| FINN | He fled down the Mississippi with a runaway slave, in fiction |
| SKIS | German organisation admits Greek letter takes one down the slippery slope (4) |
| BUNT | Lay one down the line |
| STATIONER | Trader in railway location, one down the line from Victoria |
| SOMEDAY | Protest over cuts for one down the road |
| WEBTOED | 1. Down the tube, huntaway is like a duck (3-4) |
| YAZOO | Mississippi river to the Mississippi River |
| TWAIN | Mark -, pen name of the author of The Prince and the Pauper who also wrote about the adventures of Huckleberry Finn and Tom Sawyer (5) |
| MARKTWAIN | The films, The Million Pound Note and The Prince And The Pauper were based on works by this Huckleberry Finn author (4,5) |
| RAFTS | River transports like the one used by Huckleberry Finn |
| HOOVERDATUM | "The first occupant of the White House to be born west of the Mississippi River," e.g.? |
| PLAINS | A term for the many Native American tribes once occupying an area from the Mississippi river to the Rocky mountains (6,7) |
| INDIANS | A term for the many Native American tribes once occupying an area from the Mississippi river to the Rocky mountains (6,7) |
| SPACENEEDLE | Iconic observational tower of Seattle which which was the tallest building west of the Mississippi River at the time it was built: 2 wds. |
| DELTA | Large US airline named for the southern region of the Mississippi River |
| TENNESSEE | U.S. state lying between the Mississippi River and the Smoky Mountains |
| MINNEAPOLIS | The largest city in Minnesota, located on the Mississippi River (11) |
| ARKANSAS | US state west of the Mississippi River, nicknamed 'the Natural State' (8) |
