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20 answers for: It's a major pain
RANKANSWERCLUE
AGONYIt's a major pain
ABIGAILKing David's wife could be a major pain (1 Sam. 25:23) (7)
HASSLEMajor pain in the neck
NOOSEMajor pain in the neck
PILLMajor pain
ACHEMajor pain
BREAKTHROUGHIt's a major advance to penetrate (12)
DSHARPIt's a major third above B
SAGAIt's a major account
AGONIESMajor pains
HECATOMBHusband erecting splendid memorial - it's a major sacrifice
LANDMARKIt's a major achievement to settle down near old European capital (8)
TOWNLondon? It's a major effort, going to it
CEMENTStick? It's a major part of inducement (6)
CRISISAbout Sunak's lacking height: it's a major problem
CAPTAINIn the Australian army, a ranking above a lieutenant and below a major (7)
AVALANCHEIs a large snowdrop a symbol of a major collapse? (9)
ROYALPAINEIf a competitor of Coke and Pepsi merged with a major investment firm, they'd be ___
FANNIEPACIf a major mortgage lender merged with a West Coast phone company, they'd be ___
IRSLongtime record label that shares its inits. with a major government agcy.