| DRWHO | Long-running sci-fi show, for short |
| STAR | Long-running sci-fi show with William Shatner, _ Trek (4) |
| STARTREK | Long-running sci-fi series |
| WHO | Doctor -, long-running sci-fi TV series (3) |
| REDDWARF | Long-running sci-fi sitcom starring Craig Charles (3,5) |
| TREK | Star _, long-running sci-fi franchise (4) |
| APE | Primate in a long-running sci-fi franchise |
| DOCTORWHO | Long-running sci-fi series in which Patrick Troughton played the first regenerated Time Lord (6,3) |
| DOCTOR | _ Who, long-running BBC sci-fi show (6) |
| DRWHOSYOURDADDY | "The paternity results are in ... it's the protagonist of a long-running BBC sci-fi show!"? |
| HYPERSPACE | Advertiser’s rate for feature during sci-fi show? |
| LIMITS | "The Outer ___" ('60s sci-fi show) |
| THEPOWDERLIMITS | Donut maker's favorite sci-fi show? |
| HEROES | Sci-fi show that costarred Hayden Panettiere and Zachary Quinto |
| ROSWELL | Sci-fi show demonstrated by sombreros Wellingtonians wore (7) |
| FLASHGORDON | Character from sci-fi show briefly meeting general |
| CARBON | Netflix sci-fi show, Altered... (6) |
| RED | ___ Dwarf, sci-fi show (3) |
| ALTERED | Dystopian sci-fi show set in 2384, ___ Carbon (7) |
| INSPACE | Sci-fi show rebooted in 2018, Lost ... (2,5) |
