| SYMPTOM | Most mistakenly hold my back pain, at first, was a sign of disease (7) |
| NAPPYRASH | Any sharp pain at first aggravated baby's discomfort |
| AUGURED | Foretold; was a sign of (7) |
| MARINER | The name for any of a series of ten uncrewed U.S. space probes sent to the vicinities of Venus, Mars, and Mercury between 1962 and 1973. The first was launched July 22, 1962, but was destroyed shortly |
| ATTACHE | A temperance advocate and a pain, at the embassy? (7) |
| REACTOR | The UK's first was opened at Calder Hall in Cumbria in 1956 (7) |
| MEASLES | Spots signs of disease (7) |
| SUSTAIN | Hold my group in spot (7) |
| TEACHER | Tutor gets the hollow pain at end of semester (7) |
| BOOSTER | Additional dose that makes sure the first was effective (7) |
| JUKEBOX | Musical coin-operated device, the first was unveiled in San Francisco in 1889 (7) |
| EARACHE | Pain at the side of the face (7) |
| PIRANHA | Mostly hard pain at sea to get predatory fish (7) |
| ENGLISH | Martin Van Buren's second language (his first was Dutch!) |
| SPINACH | Developed pains at church from a vegetable (7) |
| BLED | Was very sorry mum, at first, was hard to understand (4) |
| WAGER | At first, was time right to take a chance? (5) |
| LONELY | The Spanish young man at first was in need of company (6) |
| ALEHOUSE | Ivy was a sign of this bitter place (8) |
| GNOMON | Its shadow was a sign of the times (6) |
