| PLAGUE | Name a highly infectious, usually fatal, epidemic disease (6) |
| PESTILENCE | Fatal epidemic disease (10) |
| GLANDERS | A highly-infectious disease of horses caused by Actinobacillus mallei (8) |
| SOUTHAFRICA | Country thought to be the source of a highly infectious Covid-19 variant (5,6) |
| CJD | Rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus. |
| DYNAMITE | Name a highly explosive nitroglycerine mixture (8) |
| PASTRAMI | Name a highly seasoned shoulder cut of smoked beef (8) |
| CYANIDE | Name a highly poisonous substance (7) |
| DUTCHELMDISEASE | Fungal, usually fatal, ailment of certain trees (5,3,7) |
| MEASLES | Highly infectious viral disease causing fever and a red rash (7) |
| LURGI | The dreaded ____, facetious term for a fictitious, highly infectious disease, originating on The Goon Show (5) |
| INFLUENZA | Highly infectious viral disease (9) |
| MONO | Highly infectious disease, for short |
| ANTHRAX | Highly infectious disease of cattle |
| CHOLERA | Highly infectious, deadly disease (7) |
| PESTILENCES | Epidemic outbreaks of deadly and highly infectious diseases (11) |
| MYXOMATOSIS | Highly infectious disease of rabbits (11) |
| SARS | Epidemic disease, severe acute respiratory syndrome |
| PESTILENT | Likely to spread epidemic disease (9) |
| VIRULENT | Highly infectious (disease) |
