| CEBU | Pacific island Magellan visited in 1521 |
| VENUS | Magellan visited it |
| LEYTE | Philippine island discovered in 1521 by Magellan |
| AZTEC | Member of a state in central Mexico that was conquered by Cortes in 1521 - as in Choisya x dewitteana '___ Pearl' (5) |
| PEARL | Member of a state in central Mexico that was conquered by Cortes in 1521, followed by an oyster gem - as in the cultivar of Choisya x dewitteana (5,5) |
| MAGELLAN | Ferdinand ___, Portuguese navigator killed in the Philippines in 1521 (8) |
| WORMS | City of SW Germany in which Martin Luther defended his doctrines to the Holy Roman emperor Charles V in 1521 (5) |
| AZTECS | They were conquered in 1521 |
| SANJUAN | Western Hemisphere city founded in 1521 |
| M | Lutheranism in 1521, e.g. |
| DIETOFWORMS | Assembly trying Luther in 1521 |
| FERDINANDMAGELLAN | Explorer who discovered the Philippines in 1521 |
| JUAN | San ___, capital founded in 1521 |
| EMPIRE | Aztec ___ (central Mexican realm that was conquered by Cort+s in 1521) |
| OFWORMS | Conference at which Luther was named a heretic, in 1521 (4,2,5) |
| DIET | Conference at which Luther was named a heretic, in 1521 (4,2,5) |
| MARTINLUTHER | German leader of the Protestant Reformation excommunicated and outlawed by the Diet of Worms in 1521 |
| MEXICOCITY | Modern name of the settlement conquered by Cortes in 1521 (6,4) |
| LAPUTAB | Floating island visited in "Gulliver's Travels" |
| BALI | Indonesian island visited in Eat Pray Love |
