| KILLER | Pain or serial |
| PART | Actor or actress's role in a play or film; a division of a book or serial; or, a fraction of a whole (4) |
| PODCAST | "Another Round" or "Serial," for example |
| NUMBER | Issue of a periodical or serial (6) |
| REMORSEFUL | Feeling or expressing pain or sorrow for sins or offenses. Synonyms: contrite, rueful |
| RELIEF | From "raise up", a word for deliverance from burden, pain or stress; comfort thereafter; a sculpture protruding from a background; a rest or breather; or, aid to the poor (6) |
| STAB | A jab, prong or thrust with a poniard or figuratively made in the dark when randomly guessing; an attempt; a pain; or, a single staccato note (4) |
| HARM | Physical, moral or mental pain or suffering (4) |
| SUFFER | Undergo or be subjected to pain or punishment (6) |
| TEMPLES | Sections of the human head where pain or throbbing is most likely during a headache or migraine (7) |
| ROAR | A loud, deep, hoarse sound made by a lion, a person in pain or in rage or excitement |
| ACUTE | Extreme or severe like pain or water shortage |
| CRUEL | Willfully or knowingly causing pain or distress to others. (5) |
| RHEUMATISM | Pain or stiffness in the joints or muscles (10) |
| TORMENT | Severe physical or mental pain or anguish (7) |
| TOLERANCE | The ability to resist or endure pain or hardship (9) |
| WINCE | Sharp inhalation or flinch, expressing pain or shock (5) |
| ANGUISH | Severe mental or physical pain or suffering (7) |
| INFERNO | Alluding to Dante's description of a journey through hell, a word for perdition; a fire raging out of control; or, any hellish place of pain or turmoil (7) |
| PINCHANERVE | Cause pain or numbness, maybe |
