| VEGETATION | Plant life of an area (10) |
| FLORA | Plant life of an area (5) |
| FAUNA | Animal life of an area (5) |
| POCANONTAS | Celebrated Native American girl said to have saved the life of an early English settler. (10) |
| GETYOURGUN | 1946 musical with songs and lyrics by Irving Berlin, a fictionalised version of the life of an American frontier character (5,3,4,3) |
| SHENANDOAH | A portion of the trail runs through ___ National Park, noted for spectacular panoramic views and being an example of an area that had been overused but was allowed to return to its natural state (10) |
| SUBSIDENCE | The gradual sinking of an area of a land (10) |
| LANDOWNING | Being the possessor of an area of countryside |
| POPULATION | Inhabitants of an area (10) |
| TOPOGRAPHY | The relief or surface configuration of an area (10) |
| DEPOPULATE | Greatly reduce the inhabitants of (an area) |
| ANNIE | 1946 musical with songs and lyrics by Irving Berlin, a fictionalised version of the life of an American frontier character (5,3,4,3) |
| ISIS | Double life of an Egyptian goddess |
| RENEE | "The Secret Life of an American Teenager" actress Olstead |
| OHAIRTHEMUSICAL | Unlikely Broadway production about the life of an atheist? |
| BIOTA | The animal and plant life of a region or period |
| PROLIFE | Supporting the right to life of an unborn; opposed to abortion (3-4) |
| SONGOFSOLOMON | 1977 novel by Toni Morrison which is about the life of an African-American man living in Michigan: 3 wds. |
| EVITA | Tim Rice and Andrew Lloyd Webber musical on the life of an Argentinian icon; Mid-Cheshire Musical Theatre Company's production (September 2019) has been nominated for best musical by the National Oper |
| GIA | Angelina Jolie starrer biographical film based on the life of an American supermodel |
