| STARIN | Play the title role |
| NOELCOWARD | Writer who turned down an invitation to play the title role in 1962's "Dr. No" |
| OLLIE | Steve Coogan and John C Reilly play the title roles in the biopic, Stan & _ (5) |
| RENEEZELLWEGER | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| RADCLIFFE | Daniel, actor who plays the title role in the film Harry Potter and the Order of the Phoenix (9) |
| EWANMCGREGOR | Beauty and the Beast actor who plays the title role in the new movie Christopher Robin: 2 wds. |
| BENPLATT | The Politician star who plays the title role in the movie adaptation of Dear Evan Hansen: 2 wds. |
| KEANUREEVES | The Matrix actor who plays the title role in the new film John Wick: Chapter 4: 2 wds. |
| KAREN | Which woman's name is the title of three TV series, including one directed by Carl Bellamy in 1964 where Debbie Watson plays the title role? (5) |
| FRANKSINATRA | He plays the title role in the 1967 movie, Tony Rome (5,7) |
| COLTER | Mike who plays the title role in the Netflix series 'Luke Cage' |
| ZELLWEGER | Who plays the title role in the Bridget Jones films? (9) |
| OKANE | Who plays the title role in the forthcoming Christina Noble biopic? (5) |
| ARMITAGE | Child actor Iain who plays the title role in "The Big Bang Theory" spin-off "Young Sheldon" |
| TOMELLIS | Actor who plays the title role in the American TV series Lucifer (3,5) |
| EMILYBLUNT | Actress who plays the title role in the 2018 musical fantasy film Mary Poppins Returns (5,5) |
| JASONMOMOA | Conan the Barbarian star who plays the title role in Aquaman: 2 wds. |
| SAOIRSE | And 32. Actress who plays the title role in the 2018 film Mary Queen of Scots (7,5) |
| RONAN | Actress who plays the title role in the 2018 film Mary Queen of Scots (7,5) |
| LARSON | Brie ___ plays the title role in the superhero film, Captain Marvel (6) |
