| PUNTA | Port in Chile on the Strait of Magellan which is the most southerly in the world (5) |
| ARENAS | Port in Chile on the Strait of Magellan which is the most southerly in the world (6) |
| PUNTAARENAS | City in Chile, most southerly in the world (5,6) |
| FUEGO | Archipelago at the southern extremity of South America separated from the mainland by the Strait of Magellan; Spanish, ' land of fire' (6,3,5) |
| START | - Point; promontory between Dartmouth and Salcombe on the most southerly headland in Devon, site of a lighthouse maintained by Trinity House (5) |
| MACON | Portmanteau word for smoked and salted mutton; or, an appellation of red, rose or white wine produced in the most southerly Burgundian terroir (5) |
| PELEE | Point ___ (Located in Ontario, it's the most southerly point of Canada's mainland) |
| IBIZA | Which is the most westerly of the Balearic Islands? (5) |
| APPLE | ___ Inc. American technology company of Macintosh fame which is the most valuable brand according to Forbes in 2019 |
| PERAK | North-western state of Malaysia on the Strait of Malacca; capital, Ipoh (5) |
| CREEP | Which is the most played Radiohead song on Spotify? (5) |
| OBAMA | U.S. president with the most southerly birthplace |
| TIERRADELFUEGO | An archipelago off the southernmost tip of South America, across the Strait of Magellan (6,3,5) |
| SPAIN | Land on the Strait of Gibraltar |
| WILLIWAW | Sudden strong gust of cold wind such as that in the Strait of Magellan (8) |
| AKRON | Dweller on the Straits of Johor |
| STATEN | Island which is the most southerly point of New York state (6) |
| LANDSEND | One of the main locations on the route of a LEJOG or JOGLE event which is the most south-westerly point of mainland Britain (5,3) |
| CONTINENTALDIVIDE | It extends from the Bering Strait to the Strait of Magellan |
| ATACAMA | And 39 Large arid region of northern Chile on the Pacific coast west of the Andes mountains (7,6) |
