| PADUCAH | Port in Kentucky on the Ohio river with an atomic energy plant (7) |
| FRANKFORT | State capital (since 1792), of Kentucky, on the Kentucky River east of Louisville (9) |
| HONKYTONK | Piano music with sound of horn? Not in Kentucky, on reflection (5-4) |
| MIDWEST | The northern US states from the Ohio river to the Rockies |
| POMPANO | Fish in Italian river with an old, inspiring politician (7) |
| TRITIUM | Isotope with an atomic weight of three (U TRIM IT anagram) (7) |
| TROTSKY | Old Russian revolutionary jogs near Kentucky, on vacation (7) |
| CINCINNATI | City in SW Ohio, US, on the Ohio River (10) |
| EYEBANE | Examine placing restriction on energy plant |
| EVANSVILLE | City in Indiana, US on the Ohio River home to Mesker Park Zoo and Botanic Garden (10) |
| PITTSBURGH | Pennsylvania city on the Ohio River (10) |
| KNOX | Fort on the Ohio River |
| WESTVIRGINIAN | Of a US state bounded by the Appalachians to the east and the Ohio River to the west (4,9) |
| WABASH | A 503-mile-long river that is the largest northern tributary of the Ohio River (6) |
| NEON | Chemical element with an atomic number of 10, as in the toadflax cultivar ' Lights', and the scented pink Dianthus '___ Star' (4) |
| OMAHA | City in a state of Nebraska (USA) named after an Indian tribe who settled there upon migrating from the Ohio river valley |
| ALLEGHENY | River running through New York and Pennsylvania that is a principal tributary of the Ohio River |
| ALI | Olympic champion who said he threw his gold medal into the Ohio River |
| NIGERIAN | I follow river with an inhabitant of Ibadan (8) |
| CHEMICALELEMENT | Substance with an atomic number (8,7) |
