| MARACAIBO | Second-largest city of Venezuela, founded as Nueva Zamora by Spanish settlers in 1574 (9) |
| ASUNCION | Capital city and chief port of Paraguay, founded by Spanish settlers in 1537 (8) |
| CHIHUAHUA | Breed of small toy dog introduced into Mexico by Spanish settlers (9) |
| CARACAS | Capital and largest city of Venezuela, founded in 1567 (7) |
| CHARLESIX | Catherine de' Medici and Henry II's son who ruled as king of France from 1560 until his death in 1574 (7,1,1) |
| MEDICI | Cosimo de' -; first grand duke of Tuscany from 1569 until his death in 1574 (6) |
| CREOLE | In Louisiana, a French-speaking descendant of early French or Spanish settlers (6) |
| EMIGRANTS | In German, it's translated as settlers in another land (9) |
| JAMESTOWN | Sky 1 drama about the first female settlers in America (9) |
| HUGUENOTS | Poor French settlers in South Africa (9) |
| CHALUTZIM | Immigrant settlers in church plan to keep move on ice |
| SEATTLE | Largest city of America's Pacific Northwest, founded by European settlers in 1851 (7) |
| DUNEDIN | City in New Zealand founded by Scottish settlers in 1848 (7) |
| SUCRE | Capital founded as Ciudad de la Plata de la Nueva Toledo |
| LUSAKA | Capital of Zambia, founded by European settlers in 1905 (6) |
| ACADIAN | Any of the early French settlers in Nova Scotia, many of whom were deported to Louisiana in the 18th century |
| HORSA | One of two legendary leaders of the first Anglo-Saxon settlers in Britain (5) |
| AGHAST | Earliest of settlers in a mountain range in India, speechless (6) |
| WAGONTRAIN | A convoy of covered horse-drawn vehicles used by settlers in the U.S. (5,5) |
| NUEVAYOL | Bad Bunny song that samples "Un Verano en Nueva York," by El Gran Combo de Puerto Rico |
