| TWINPEAKS | Series on which Kyle MacLachlan plays FBI Special Agent Dale Cooper: 2 wds. |
| KYLEMACLACHLAN | Portlandia actor who played FBI Special Agent Dale Cooper on Twin Peaks: 2 wds. |
| PORTLANDIA | Series on which Kyle MacLachlan portrays the mayor of an Oregon city |
| DESPERATE | With 26-Across, series on which Kyle MacLachlan portrayed Wisteria Lane resident Orson Hodge |
| SOFTKITTY | Song about a cuddly feline, sung to Sheldon Cooper: 2 wds. |
| JIMPARSONS | Shown, he's Sheldon Cooper: 2 wds. |
| PEAKS | Cult '90s series with Kyle Maclachlan as Special Agent Dale Cooper, Twin ___ (5) |
| KYLE | Actor who played Special Agent Dale Cooper in 1990s US TV how Twin Peaks (4,10) |
| TWIN | US television series that starred Kyle MacLachan as Agent Dale Cooper (4,5) |
| KEVINBACON | The Following actor who plays FBI agent Jackie Rohr on Showtime's City on a Hill: 2 wds. |
| SCULLY | FBI Special Agent in the sci-fi television series The X-Files (6) |
| TYRESEGIBSON | The Fate of the Furious actor who plays FBI agent Simon Stroud in Morbius: 2 wds. |
| NOWYOUSEEME | 2013 heist film in which Mark Ruffalo plays FBI agent Dylan Rhodes: 4 wds. |
| SEELEY | David Boreanaz stars as FBI Special Agent ___ Booth in Bones (6) |
| ANDERSON | Gillian -, stars as FBI Special Agent Dana Scully in The X-Files (8) |
| GILLIANANDERSON | Actress who found fame playing FBI Special Agent Dana Scully in The X-Files (7,8) |
| MULDER | Fox, FBI Special Agent played by David Duchovny in The X-Files (6) |
| GMAN | FBI special agent, for short (hyph.) |
| MAYFAIRWITCHES | 2023-debuting supernatural series on which Canadian actress Suleka Mathew plays a magical healer: 2 wds. |
| BOONE | Plays FBI agent Elizabeth Keen in The Blacklist, Megan ----- (5) |
