| FORMENTERA | Smallest of the four main Balearic Islands (10) |
| MAJORCA | Main Balearic island |
| SHIKOKU | The smallest of the four main islands of Japan. It is separated from Honshu by the Inland Sea (north) and the Kii Strait (east) and from Kyushu by the Bungo Strait (west). (7) |
| SARK | Smallest of the four main Channel Islands, where the head of the island traditionally lives at La Seigneurie (4) |
| HOKKAIDO | The northernmost of the four main islands of Japan. It is bordered by the Sea of Japan (East Sea), the Sea of Okhotsk to the north, and the Pacific Ocean. (8) |
| HONSHU | The largest of the four main islands of Japan (6) |
| INLANDSEA | Body of water separating three of the four main islands of Japan (6,3) |
| SUDRA | The lowest of the four main Hindu castes, the workers (5) |
| EAST | One of the four main points of the compass |
| KYUSHU | Southernmost and third largest of the four main islands of Japan. (6) |
| HUTU | Largest of the four main ethnic groups of Burundi and Rwanda (4) |
| MARSH | One of the four main characters of South Park, Stan - (5) |
| GALILEO | Discoverer of the four main moons of Jupiter (7) |
| EMERALD | One of the four main precious gems; a form of beryl traditionally used as a birthstone for May (7) |
| VELMA | One of the four main human characters in the Scooby-Doo cartoon series (5) |
| EVANGEL | Name applied to any of the four main Gospels (7) |
| CARDINALPOINT | One of the four main marks on a compass (8,5) |
| NEWS | Word that's only coincidentally made up of the four main compass points |
| EUROPA | Named after the mother of Minos, the smallest of the four Galilean moons of Jupiter (6) |
| EILISH | At 18, the youngest person to sweep the four main Grammy categories (Song, Album, Record, Best New Artist) in a single year |
