| STEVIA | Sugar substitute that plays a key role in "Breaking Bad" |
| EQUAL | Sugar substitute that comes in a blue package |
| SAUL | Bob Odenkirk's titular role in Breaking Bad's off-shoot |
| TAKINGAPART | Accepting a role in Breaking Up (6,5) |
| CAVES | Fictional tourist attraction that plays a key role in E M Forster's 1924 novel A Passage to India (7,5) |
| MARABAR | Fictional tourist attraction that plays a key role in E M Forster's 1924 novel A Passage to India (7,5) |
| TCELL | Lymphocyte that plays a key role in immune defence |
| CORTEX | Outer part of the brain that plays a key role in consciousness (6) |
| ROLLO | Invented killer whose name plays a key role in the film "L.A. Confidential," ___ Tomasi |
| BURKE | Edmund ___, British statesman who played a key role in the impeachment of Warren Hastings in the late 18th century (5) |
| BERTHA | ______ von Suttner became, in 1905, the first woman to win the Peace Prize; she played a key role in creating the Nobel Peace Prize as well |
| YAMAHA | Japanese company who played a key role in producing Toyota's 2000GT (6) |
| STOINIS | Australian all-rounder who has played a key role in Delhi's 2020 victories |
| JOANOFARC | Saint who played a key role in the Siege of Orléans |
| BRAUN | Wernher von ___, German scientist who played a key role in America's space programme (5) |
| THEGANGOFFOUR | Chinese political faction which played a key role in the Cultural Revolution (3,4,2,4) |
| BELL | Author and archaeologist who played a key role in the creation of Iraq (8,4) |
| GERTRUDE | Author and archaeologist who played a key role in the creation of Iraq (8,4) |
| WOAKES | England seamer and all-rounder playing for Delhi since 2020, he played a key role in England's 2019 ODI World Cup win |
| RICH | Henry VIII's minister who played a key role in the trials of Sir Thomas More and John Fisher as well as the downfall of Sir Thomas Cromwell and the dissolution of the monasteries (4) |
