| DAVIDTENNANT | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| MATTSMITH | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| PETERCAPALDI | Twelfth actor to play the lead role in 15-Across (2013-present): 2 wds. |
| JODIEWHITTAKER | First woman to play the lead role in Doctor Who (5,9) |
| SARAH | Who, in 1899, became one of the few women to play the lead in Hamlet? (5,9) |
| BERNHARDT | Who, in 1899, became one of the few women to play the lead in Hamlet? (5,9) |
| STEVEMARTIN | L.A. Story actor whose The Crow: New Songs for the 5-String Banjo won the Best Bluegrass Album Grammy in 2010: 2 wds. |
| HARTNELL | William ___, the first actor to play the Doctor in Doctor Who back in 1963 (8) |
| ELISABETHMOSS | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| CRISTIEKERR | American golfer who was #1 in the LPGA for five weeks in 2010: 2 wds. |
| LORENAOCHOA | Mexican golfer who was #1 in the LPGA from April 2007 to May 2010: 2 wds. |
| MIKENICHOLS | The Graduate director who received the AFI Life Achievement Award in 2010: 2 wds. |
| KARENBASS | Former Congressional Black Caucus chair who received the Profile in Courage Award in 2010: 2 wds. |
| NATEROBINSON | Only player to win the NBA Slam Dunk Contest three times in 2006 2009 and 2010: 2 wds. |
| BROSNAN | Fifth actor to play the role of 007, starring in four James Bond films (7) |
| MICHAELMCKEAN | Better Call Saul actor who won 1,000,000 for charity on the Jeopardy Million Dollar Celebrity Invitational in 2010: 2 wds. |
| STAR | Play the lead role (4) |
| ROYHALLADAY | Phillies pitcher who threw two no-hitters in a single season in 2010: 2 wds. |
| LAURENJACKSON | Former Seattle Storm player who was named the WNBA MVP in 2003 2007 and 2010: 2 wds. |
| SAMBRADFORD | University of Oklahoma quarterback who was drafted #1 overall by the St. Louis Rams in 2010: 2 wds. |
