| CHEPSTOW | Town in Monmouthshire on the River Wye which is the site of a cliff-top Norman stronghold (8) |
| HUER | According to Cornish tradition, a cliff-top lookout-man alerting fishermen and townsfolk to the arrival of approaching pilchard shoals (4) |
| MONMOUTH | Town in southeast Wales near the border with England at the confluence of the Rivers Wye and Monnow (8) |
| BAKEWELL | Derbyshire town on the River Wye, noted for its eponymous pudding and tart (8) |
| HEREFORD | Cathedral city in England on the River Wye (8) |
| DORDOGNE | Department in France which is the site of the Lascaux cave (8) |
| RIBOSOME | Particle which is the site of protein synthesis in a cell |
| BOTHERED | Troubled bloke crossing the river Wye at last |
| TINTERN | Cistercian abbey founded in 1131 on the Welsh bank of the River Wye in Monmouthshire (7) |
| CROCKERY | Service cliff-top garden feature (8) |
| CORNICHE | My husband blocks pleasant cliff-top road (8) |
| ABERGAVENNY | Market town in Monmouthshire, Wales, on the north bank of the River Usk housing an 11th-century castle (11) |
| TINTERNABBEY | Ruin situated on the River Wye in Monmouthshire (7,5) |
| HIGHWYCOMBE | Town in Buckinghamshire on the River Wye northeast of Reading (4,7) |
| DURHAM | City in a county which is the site of the Bowes Museum and Raby Castle (6) |
| MILE | Royal -; thoroughfare which is the site of Edinburgh Castle, the Palace of Holyroodhouse and the Scottish Parliament Building (4) |
| LIVORNO | Port city in Tuscany which is the site of the Italian Naval Academy (7) |
| SEQUOIA | National Park in central California which is the site of the world's largest tree by volume, General Sherman (7) |
| DUMBARTONROCK | Volcanic plug overlooking the Clyde which is the site of an historically mighty stronghold (9,4) |
| IONA | Island in the Inner Hebrides which is the site of St Columba's monastery (4) |
