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20 answers for: Travels around isthmus, heading off Central Americ...
RANKANSWERCLUE
GECKOESTravels around isthmus, heading off Central American natives
MAYACentral American Native American
COATIPaint one Central American native (5)
ROADRUNNERCentral American native reportedly went on racehorse (10)
MULCHConsider -- having left off central heating -- bed cover (5)
SHOOTOpen fire to drive off central heating (5)
AFARA long way off central safaris
RUNSOperates historic site, perhaps, closing off central section
CARIBBEANSea off Central America (9)
WESTINDIESArchipelago off Central America, separating the Caribbean Sea from the Atlantic Ocean (4,6)
ESKIMOSArctic American natives now referred to as Inuit
COYPUSSouth American natives' secretive, secretive matter?
MOSQUITOSAmerican natives and doctor help us to cross desert
MICHAELMASDAISIES
North American natives might become Islamicised - a shame?
TRIBEDivision of, eg, North American natives
INCASSouth American natives, once
SOULMUSICMixture of melodies to entertain foottapping American natives, one hears? (4,5)
BLOWPIPEEquipment used by glass workers and South American natives (8)
LLAMASSome South American natives
CURAREBlack resin used as an arrow poison by South American Natives (6)