| ISAACSINGER | US inventor who collaborated with others to produce the first commercially successful sewing machine (1851) |
| SINGER | Inventor who designed, built and patented the first commercially successful sewing machine (6) |
| ADAM | Did a mother produce the first man? |
| ACETAL | A chemist's first, with others, to produce a compound |
| AMINOACID | A molecule in the body that combines with others to produce protein (5,4) |
| COFFEEMAKER | Appliance that produces the first words of the answers to this puzzle's longest entries |
| COCHRANE | Inventor who patented the first commercially successful dishwasher in 1886 (9,8) |
| JOSEPHINE | Inventor who patented the first commercially successful dishwasher in 1886 (9,8) |
| IGORSIKORSKY | Which Russian-born US aircraft designer was responsible for the first commercially successful helico |
| DEERE | John ---, American blacksmith and manufacturer who invented the first commercially successful steel plough in 1837 (5) |
| PINGPONG | Basis for the first commercially successful video game |
| OLDS | Creator of the first commercially successful American auto |
| WOZNIAK | Designer of the first commercially successful personal computer |
| TELE | Made by Fender, the common name of the world's first commercially successful solid-body electric guitar (4) |
| HOWE | US inventor who patented the world's first lockstitch sewing machine (4) |
| ELIASHOWE | US inventor who patented the first lockstitch sewing machine in 1846 (5,4) |
| PONG | First commercially successful video game released by Atari in 1972 that involves playing table tennis |
| LEOFENDER | US inventor who developed the first massproduced solid- body electric guitar, the Telecaster, in 1951 (3,6) |
| GATLING | Richard J. ___, US inventor who patented the first practical machine gun in 1862 (7) |
| ORLON | First commercially successful acrylic fiber |
