| PHI | What is the 21st first letter of the Greek alphabet? (3) |
| ANSELM | Saint and philosopher born in 11th-century Italy whose feast day is the 21st of April (6) |
| CENTURY | This is the 21st horseman, you could say, dispatching a Yankee |
| OKLAHOMA | US state where the first letter of the capital city matches the first letter of the state (8) |
| HAWAII | US state where the first letter of the capital city matches the first letter of the state (6) |
| DELAWARE | US state where the first letter of the capital city matches the first letter of the state (8) |
| INDIANA | US state where the first letter of the capital city matches the first letter of the state (7) |
| ALPHA | What is the first letter of the Greek alphabet? (5) |
| AIN | What is the 16th letter of the Hebrew, Aramaic and Syriac scripts and the 21st of the Persian alphabet? (3) |
| ALIF | The first letter of the Arabic alphabet (from the same root as Greek's "alpha") |
| AGAME | Colloquialism, drawing on the established association of the first letter of the alphabet with excellence, for one's top performance (1,4) |
| ALEPH | First letter of the Phoenician and of the Hebrew alphabet (5) |
| AMAZONA | South American river followed by the first letter of the alphabet (7) |
| AFRAME | House that looks like the first letter of the alphabet: Hyph. |
| ACLASS | Mercedes-Benz car named for the first letter of the alphabet |
| DISUNION | State of division, and what the first letters of the states divided across black squares in this puzzle spell out |
| ALEF | First letter of the Hebrew alphabet (var.) |
| INITIAL | To begin it, I always included the first letter of the word |
| SHIN | Twenty-first letter of the Hebrew alphabet, literally meaning 'tooth' (4) |
| ALFA | First letter of the NATO phonetic alphabet |
