| LIST | Winner of the 2021 Nobel, together with David MacMillan, for the development of asymmetric organocatalysis (last name only) |
| MARIA | Filipino journalist who shared the 2021 Nobel Peace Prize with Russian journalist Dmitry Muratov (5,5) |
| RESSA | Filipino journalist who shared the 2021 Nobel Peace Prize with Russian journalist Dmitry Muratov (5,5) |
| UCLA | Where Ardem Patapoutian, 2021 Nobel Prize winner in medicine, got his undergrad degree in biology |
| HER | One-named winner of the 2021 Grammy for Song of the Year |
| LITHIUMION | In 2019 John B. Goodenough, M. Stanley Whittingham, and Akira Yoshino won the Chemistry Nobel for the development of what kind of batteries? (7-3) |
| ELISEMERTENS | Belgian winner of the 2021 Wimbledon women’s doubles, with Hsieh Su-wei |
| KIPP | Dutch chemist/pharmacist who invented an elaborate piece of laboratory glassware for the development of gases, such as carbon dioxide or hydrogen sulphide (4) |
| AEC | Former U.S. government agency formed for the development of atomic science and technology: Abbr. |
| OASES | So you need sea for the development of fertile places (5) |
| MILLER | Winner of the 2021 I'm A Celebrity series (5,6) |
| DANNY | Winner of the 2021 I'm A Celebrity series (5,6) |
| DANNYMILLER | Winner of the 2021 I'm A Celebrity... series (5,6) |
| KORDA | Nelly ....., winner of the 2021 Women's PGA Championship and 2024 Chevron Championship; 2020 Olympics golf gold medallist (5) |
| ZIONIST | Follower of a movement for the development and protection of a Jewish nation in Israel (7) |
| MEDINA | ___ Spirit, winner of the 2021 Kentucky Derby |
| NOMADLAND | Winner of the 2021 Best Picture Oscar (9) |
| ASHLEIGHBARTY | Winner of the 2021 Wimbledon women's singles |
| NOVAKDJOKOVIC | Winner of the 2021 Wimbledon men's singles |
| AMANDAGORMAN | "The Hill We Climb" poet who was one of the cohosts of the 2021 Met Gala: 2 wds. |
