| PICO | __ de Aneto (highest of the Pyrenees) |
| NETHOU | Pic de ___, highest of the Pyrenees |
| ANETO | Highest of the Pyrenees, Pico de ___ |
| PYRENEES | Mountain range along the FrancoSpanish border with the highest peak Pico de Aneto; home of the griffon vulture (8) |
| DUKE | Derived from the Latin word "dux" (leader), the highest of the five ranks of the peerage (4) |
| SERAPH | An angel of the highest of the nine orders (6) |
| PERPIGNAN | French town located at the foot of the Pyrenees near the border with Spain, in the 13th century it was the continental capital of the then Kingdom of Mallorca (9) |
| RORAIMA | Described as an "island in the clouds", highest of the Pacaraima Mountains which inspired Arthur Conan Doyle's The Lost World (7) |
| TENOR | The highest of the ordinary adult singing voice |
| ABOVEALL | The highest of the high, in particular (5,3) |
| BLOTTO | What the highest of the high are (6) |
| ACONCAGUA | Andean mountain which is the second-highest of the Seven Summits (9) |
| MAGNACUMLAUDE | Second-highest of the three designations of excellence in US universities; Latin, literally 'with great praise' (5,3,5) |
| RAINIER | Highest of the Cascades |
| ROSA | Monte ___ (second-highest of the Alps) |
| ACE | Highest of the honors in bridge |
| MONT | ___ Blanc, highest of the Alps |
| MONTE | ___ Leone, highest of the Lepontine Alps |
| BLANC | Mont ___, highest of the Alps |
| SERAPHIM | Highest of the celestial hierarchy |
